Are Liars Ethical? On the Tension between Benevolence and Honesty

We demonstrate that some lies are perceived to be more ethical than honest statements. Across three studies, we find that individuals who tell prosocial lies, lies told with the intention of benefitting others, are perceived to be more moral than individuals who tell the truth. In Study 1, we compare altruistic lies to selfish truths. In Study 2, we introduce a stochastic deception game to disentangle the influence of deception, outcomes, and intentions on perceptions of moral character. In Study 3, we demonstrate that moral judgments of lies are sensitive to the consequences of lying for the deceived party, but insensitive to the consequences of lying for the liar. Both honesty and benevolence are essential components of moral character. We find that when these values conflict, benevolence may be more important than honesty. More broadly, our findings suggest that the moral foundation of care may be more important than the moral foundation of justice

Prosocial Lies: When Deception Breeds Trust

Philosophers, psychologists, and economists have long asserted that deception harms trust. We challenge this claim. Across four studies, we demonstrate that deception can increase trust. Specifically, prosocial lies increase the willingness to pass money in the trust game, a behavioral measure of benevolence-based trust. In Studies 1a and 1b, we find that altruistic lies increase trust when deception is directly experienced and when it is merely observed. In Study 2, we demonstrate that mutually beneficial lies also increase trust. In Study 3, we disentangle the effects of intentions and deception; intentions are far more important than deception for building benevolence-based trust. In Study 4, we examine how prosocial lies influence integrity-based trust. We introduce a new economic game, the Rely-or-Verifygame, to measure integrity-based trust. Prosocial lies increase benevolence-based trust, but harm integrity-based trust. Our findings expand our understanding of deception and deepen our insight into the mechanics of trust

The Affective and Interpersonal Consequences of Obesity

The incidence of obesity in the United States has tripled over the past fifty years, posing significant challenges for organizations. We build on stereotype content research and offer an overarching framework to understand individuals’ affective, cognitive, and behavioral responses to obesity. Across five studies, we demonstrate that individuals associate obesity with perceptions of low competence. Perceptions of low competence predict affective (disgust, sympathy) and behavioral (low help, high harm) responses to obesity. Consistent with the BIAS Map (Cuddy, Fiske, & Glick, 2007), these discriminatory responses are moderated by perceptions of warmth. We demonstrate that, in some cases, shifting perceptions of warmth is just as effective as losing weight for curtailing discrimination towards the obese. Our findings demonstrate that social categorization is labile and we offer prescriptive advice for individuals seeking to change the way others perceive them

Pre-commitment to Moral Values

When faced with reoccurring tradeoffs between moral values, people can address them by considering the specifics of each case or by setting policies that predetermine how they will address similar cases. Previous research on moral judgment has often focused on isolated tradeoffs, and therefore, it is unclear which decision strategies are preferred in contexts with reoccurring tradeoffs. Across our studies, participants judged people who precommitted to always prioritizing one value more positively than people who adjusted their priorities based on the specifics of each case. Our findings have important implications for understanding public perceptions of complex policies

The Social Consequences of Absolute Moral Proclamations

Across six studies (N = 3348), we find that people prefer targets who make absolute proclamations (i.e. It is never okay for people to lie ) over targets who make ambiguous proclamations ( It is sometimes okay for people to lie ), even when both targets tell equivalent lies. Preferences for absolutism stem from the belief that moral proclamations send a true signal about moral character--they are not cheap talk. Therefore, absolute proclamations signal moral character, despite also signaling hypocrisy. This research sheds light on the consequences of absolute proclamations and identifies circumstances in which hypocrisy is preferred over consistency

Selfish Or Selfless? on the Signal Value of Emotion in Altruistic Behavior

We examine when consumers gain credit for good deeds. Contrary to theories that decry emotions as selfish, people view emotions as authentic, and therefore deserving of charitable credit. Further, feeling good as a result of giving is viewed positively, unless someone explicitly claims to have been motivated by emotional benefits. [to cite]

Safety and efficacy of arimoclomol for inclusion body myositis: a multicentre, randomised, double-blind, placebo-controlled trial

BACKGROUND: Inclusion body myositis is the most common progressive muscle wasting disease in people older than 50 years, with no effective drug treatment. Arimoclomol is an oral co-inducer of the cellular heat shock response that was safe and well-tolerated in a pilot study of inclusion body myositis, reduced key pathological markers of inclusion body myositis in two in-vitro models representing degenerative and inflammatory components of this disease, and improved disease pathology and muscle function in mutant valosin-containing protein mice. In the current study, we aimed to assess the safety, tolerability, and efficacy of arimoclomol in people with inclusion body myositis. METHODS: This multicentre, randomised, double-blind, placebo-controlled study enrolled adults in specialist neuromuscular centres in the USA (11 centres) and UK (one centre). Eligible participants had a diagnosis of inclusion body myositis fulfilling the European Neuromuscular Centre research diagnostic criteria 2011. Participants were randomised (1:1) to receive either oral arimoclomol 400 mg or matching placebo three times daily (1200 mg/day) for 20 months. The randomisation sequence was computer generated centrally using a permuted block algorithm with randomisation numbers masked to participants and trial staff, including those assessing outcomes. The primary endpoint was the change from baseline to month 20 in the Inclusion Body Myositis Functional Rating Scale (IBMFRS) total score, assessed in all randomly assigned participants, except for those who were randomised in error and did not receive any study medication, and those who did not meet inclusion criteria. Safety analyses included all randomly assigned participants who received at least one dose of study medication. This trial is registered with ClinicalTrials.gov, number NCT02753530, and is completed. FINDINGS: Between Aug 16, 2017 and May 22, 2019, 152 participants with inclusion body myositis were randomly assigned to arimoclomol (n=74) or placebo (n=78). One participant was randomised in error (to arimoclomol) but not treated, and another (assigned to placebo) did not meet inclusion criteria. 150 participants (114 [76%] male and 36 [24%] female) were included in the efficacy analyses, 73 in the arimoclomol group and 77 in the placebo group. 126 completed the trial on treatment (56 [77%] and 70 [90%], respectively) and the most common reason for treatment discontinuation was adverse events. At month 20, mean IBMFRS change from baseline was not statistically significantly different between arimoclomol and placebo (-3·26, 95% CI -4·15 to -2·36 in the arimoclomol group vs -2·26, -3·11 to -1·41 in the placebo group; mean difference -0·99 [95% CI -2·23 to 0·24]; p=0·12). Adverse events leading to discontinuation occurred in 13 (18%) of 73 participants in the arimoclomol group and four (5%) of 78 participants in the placebo group. Serious adverse events occurred in 11 (15%) participants in the arimoclomol group and 18 (23%) in the placebo group. Elevated transaminases three times or more of the upper limit of normal occurred in five (7%) participants in the arimoclomol group and one (1%) in the placebo group. Tubulointerstitial nephritis was observed in one (1%) participant in the arimoclomol group and none in the placebo group. INTERPRETATION: Arimoclomol did not improve efficacy outcomes, relative to placebo, but had an acceptable safety profile in individuals with inclusion body myositis. This is one of the largest trials done in people with inclusion body myositis, providing data on disease progression that might be used for subsequent clinical trial design. FUNDING: US Food and Drug Administration Office of Orphan Products Development and Orphazyme

Effects of branching spatial structure and life history on the asymptotic growth rate of a population

Author Posting. © The Author(s), 2009. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Theoretical Ecology 3 (2010): 137-152, doi:10.1007/s12080-009-0058-0.The dendritic structure of a river network creates directional dispersal and a hierarchical arrangement of habitats. These two features have important consequences for the ecological dynamics of species living within the network.We apply matrix population models to a stage-structured population in a network of habitat patches connected in a dendritic arrangement. By considering a range of life histories and dispersal patterns, both constant in time and seasonal, we illustrate how spatial structure, directional dispersal, survival, and reproduction interact to determine population growth rate and distribution. We investigate the sensitivity of the asymptotic growth rate to the demographic parameters of the model, the system size, and the connections between the patches. Although some general patterns emerge, we find that a species’ mode of reproduction and dispersal are quite important in its response to changes in its life history parameters or in the spatial structure. The framework we use here can be customized to incorporate a wide range of demographic and dispersal scenarios.Funding for this work came from the James S. McDonnell Foundation (EEG, HJL, WFF). MGN was supported by grants from the National Science Foundation (CMG-0530830, OCE-0326734, ATM-0428122)

Recurrence Risk of Autism in Siblings and Cousins: A Multinational, Population-Based Study

Objective:Familial recurrence risk is an important population-level measure of the combined genetic and shared familial liability of autism spectrumdisorder (ASD). Objectives were to estimate ASD recurrence risk among siblings and cousins by varying degree of relatedness and by sex.Method:This is a population-based cohort study of livebirths from 1998 to 2007 in California, Denmark, Finland, Israel, Sweden and WesternAustralia followed through 2011 to 2015. Subjects were monitored for an ASD diagnosis in their older siblings or cousins (exposure) and for their ASDdiagnosis (outcome). The relative recurrence risk was estimated for different sibling and cousin pairs, for each site separately and combined, and by sex.Results:During follow-up, 29,998 cases of ASD were observed among the 2,551,918 births used to estimate recurrence in ASD and 33,769 cases ofchildhood autism (CA) were observed among the 6,110,942 births used to estimate CA recurrence. Compared with the risk in unaffected families, therewas an 8.4-fold increase in the risk of ASD following an older sibling with ASD and a 17.4-fold increase in the risk of CA following an older sibling withCA. A 2-fold increase in the risk for cousin recurrence was observed for the 2 disorders. There also was a significant difference in sibling ASD recurrencerisk by sex.Conclusion:The present estimates of relative recurrence risks for ASD and CA will assist clinicians and families in understanding autism risk in thecontext of other families in their population. The observed variation by sex underlines the need to deepen the understanding of factors influencing ASD familial risk.</p

Uncovering the complex genetics of human temperament

Experimental studies of learning suggest that human temperament may depend on the molecular mechanisms for associative conditioning, which are highly conserved in animals. The main genetic pathways for associative conditioning are known in experimental animals, but have not been identified in prior genome-wide association studies (GWAS) of human temperament. We used a data-driven machine learning method for GWAS to uncover the complex genotypic-phenotypic networks and environmental interactions related to human temperament. In a discovery sample of 2149 healthy Finns, we identified sets of single-nucleotide polymorphisms (SNPs) that cluster within particular individuals (i.e., SNP sets) regardless of phenotype. Second, we identified 3 clusters of people with distinct temperament profiles measured by the Temperament and Character Inventory regardless of genotype. Third, we found 51 SNP sets that identified 736 gene loci and were significantly associated with temperament. The identified genes were enriched in pathways activated by associative conditioning in animals, including the ERK, PI3K, and PKC pathways. 74% of the identified genes were unique to a specific temperament profile. Environmental influences measured in childhood and adulthood had small but significant effects. We confirmed the replicability of the 51 Finnish SNP sets in healthy Korean (90%) and German samples (89%), as well as their associations with temperament. The identified SNPs explained nearly all the heritability expected in each sample (37-53%) despite variable cultures and environments. We conclude that human temperament is strongly influenced by more than 700 genes that modulate associative conditioning by molecular processes for synaptic plasticity and long-term memory.Peer reviewe